Effusanin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Effusanin A 具有抗菌活性。在采用 DNA 修复缺陷型 (RAD 52Y) 和修复良好型 (RAD +) 酵母菌株的检测中，它表现出 DNA 损伤活性。 Effusanin A 对 DU145 细胞有抑制作用，IC50 值为 3.16 μM，对 LoVo 细胞有抑制作用，IC50 值为 3.02 μM。

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repairs proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 μM, and LoVo cells with IC50 value of 3.02 μM.(In Vitro):A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.

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MAPK/ERK Signaling

Raf

Raf

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30220-43-0

348.43

C20H28O5

>98% (HPLC)

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C=C([C@H](CC1)C2)C([C@@]32[C@]4(O)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5(CO4)[C@@]31[H])=O

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(-20℃)

With Ice Pack

≥ 2 years